Recombinant TNF alpha (Adalimumab Biosimilar) 抗体
This anti-TNF alpha (Adalimumab Biosimilar) antibody is a 小鼠 单克隆 antibody detecting TNF alpha (Adalimumab Biosimilar) in FACS 和 in vivo. Suitable for 人.
Quick Overview for Recombinant TNF alpha (Adalimumab Biosimilar) 抗体 (ABIN7200655)
抗原
TNF alpha (Adalimumab Biosimilar)
抗体类型
Recombinant Antibody
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This TNF alpha (Adalimumab Biosimilar) antibody is un-conjugated
应用范围
Flow Cytometry (FACS), In vivo Studies (in vivo)
质量等级
Research Grade
克隆位点
D2E7
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原理
- Adalimumab Biosimilar, TNF alpha Monoclonal Antibody
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特异性
- The monoclonal antibody adalimumab biosimilar specifically binds to the human TNF alpha.
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产品特性
- Adalimumab, the first fully human monoclonal antibody drug approved by FDA, binds to TNFα, inactivates TNF receptors, and downregulates the inflammatory reactions associated with a variety of autoimmune diseases, such as rheumatoid arthritis, psoriatic arthritis, ankylosing spondylitis, Crohn's disease, ulcerative colitis, moderate to severe chronic psoriasis and juvenile idiopathic arthritis. Mainly produced by activated macrophages (M1), Tumor necrosis factor (TNF, cachexin, cachectin, tumor necrosis factor alpha, TNFα) plays important roles in the regulation of immune cells. As a member of a group of cytokines that stimulate the acute phase reaction, TNF is involved in systemic inflammation and able to induce fever, apoptotic cell death, cachexia, inflammation, and to inhibit tumorigenesis and viral replication and respond to sepsis via IL1 & IL6 producing cells. Dysregulation of TNF expression could have serious impact in a variety of human diseases including Alzheimer's disease, cancer, major depression and inflammatory bowel disease.
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纯化方法
- Protein A or G affinity column
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纯度
- >95 % by reducing SDS-PAGE
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过滤
- 0.2 μm filtered
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内毒素水平
- < 1 EU per 1 mg of the protein by the LAL method
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免疫原
- The monoclonal antibody adalimumab biosimilar was produced in the adalimumab biosimilar CHO stable cell line.
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亚型
- IgG1
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anti-TNF alpha (Adalimumab Biosimilar) antibody
Research Grade 适用: 人 ELISA, FACS 宿主: Human Monoclonal unconjugated Recombinant Antibody
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应用备注
- ELISA, neutralization, functional assays such as bioanalytical PK and ADA assays, and those assays for studying biological pathways affected by adalimumab.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- > 3 mg/mL
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缓冲液
- PBS, pH 7.4, no stabilizers or preservatives.
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储存液
- Without preservative
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储存条件
- 4°C,-20 °C
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储存方法
- 12 months from date of receipt, -20 to -70°C as supplied. 1 month from date of receipt, 2 to 8°C as supplied.
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有效期
- 12 months
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- TNF alpha (Adalimumab Biosimilar)
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别名
- Adalimumab Biosimilar
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物质类
- Biosimilar
抗原
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